SS-31

One year later! 280 to 185 and took 4 month plateau over the winter. Not one day of exercise. I am 57 years old and I’m only posting because of the folks that say some of us do too much “research.” (i.e., too many peptides) Don’t results matter? After losing 45 lbs on keto and water fasts in about 6-7 weeks, I stepped up my game. Semaglutide? Lost zero pounds in almost 2 months. Tirz dropped 235 to 195 losing the next 40 in a couple months. Settled in for the winter and had spine surgery January 7th had a two week off period from peptides and the Tirz didn’t work when I restarted. Jumped to Reta. Two weeks ago decided to drop another 10 lbs all this without having loose skin and have been relieved of sleep apnea, high blood sugar, high cholesterol, high BP, ADHD, any signs of gout, and more. PEPTIDES: Reta, Tirz, Cagri GHK-Cu, BPC-157, TB-500 CJC, IPO, SERMO SS-31, Mots C, NAD+ Semax, Selank MT2 for color SUPPLEMENTS: TRT & B12 (IM) ORAL SUPPLEMENTS: Zinc, Magnesium, B6, B12, C, D3+K2, E, Omega-3, NMN+NR w/Resveratrol and TMG, probiotics, collagen, protein drinks, Metformin, Finesteride, and a few others. I have an MRI on May 18th to see if I am approved to exercise. If approved, I’ll work out for the first time in 30 years. Not sure what will happen then. Read more

Peptide tier list for anti-aging and longevity Ranked by what's producing the best results for aging, skin, cellular health, and long term wellness The order within each tier is not a ranking. They're just grouped by tier not listed best to worst S TIER HGH - sleep, skin, recovery, body comp, energy. The most established compound on this list with decades of clinical use. Everything about aging improves when GH levels are optimized GHK-Cu - the most researched anti-aging peptide available. Naturally occurs in the body and declines sharply with age. Modulates over 4000 genes involved in tissue remodeling, collagen synthesis, and inflammation. Human studies show improvements in skin thickness, elasticity, and wrinkle depth. Works injectable and topical Thymosin Alpha-1 - your immune system ages just like everything else. Most legitimate immune peptide with clinical use in 30+ countries. Immune modulation and inflammation control are foundational to aging well A TIER NAD+ precursors (NMN / NR) - NAD+ levels drop by as much as 50% between young adulthood and later decades. Preclinical data shows restoring levels can improve mitochondrial function, cognitive performance, and multiple aging markers. Multiple delivery routes available Epithalon - studied for telomerase activation and telomere length. Telomere shortening is one of the hallmarks of aging. Sleep and circadian rhythm support are the more immediately noticeable benefits. Human data is limited but the mechanism is directly relevant BPC-157 - tissue repair, gut health, and reducing systemic inflammation all contribute to aging better. Pro-angiogenic effects support blood vessel health which declines with age TB-500 - tissue remodeling and repair. Supports the body's ability to recover and rebuild which naturally slows down over time. Often paired with BPC-157 B TIER CJC-1295 + Ipamorelin - GH support without injecting exogenous HGH. Sleep, recovery, and body comp improvements all feed into the anti-aging picture. More affordable than HGH Sermorelin - same category as CJC/Ipa. GH support for sleep and recovery. Clinical history in wellness settings MOTS-c - mitochondrial derived peptide. Mitochondrial decay is a major driver of aging. Studied for insulin sensitivity and metabolic regulation. Human data is limited but the mechanism is directly tied to cellular aging SS-31 / Elamipretide - targets the mitochondrial inner membrane directly. Studied for mitochondrial protection and cellular energy. Highly regarded in longevity circles Semax - neuroprotection and BDNF upregulation. Cognitive decline is one of the most impactful age related changes. Protects dopaminergic neurons and reduces neuroinflammation in preclinical models Selank - cognitive preservation and neuroinflammation reduction. Neuroinflammation is increasingly recognized as a driver of systemic aging C TIER Glutathione - master antioxidant. Detoxification and immune support. Levels decline with age Collagen peptides (oral) - most accessible anti-aging option. Some clinical evidence for skin elasticity and hydration KPV - anti-inflammatory without immunosuppression. Chronic inflammation accelerates aging. KPV addresses that through NF-kB inhibition DSIP - deep restorative sleep is where repair happens. DSIP may support sleep architecture but human data is mixed Thymalin - immune and longevity peptide. Limited published evidence but immune restoration is relevant to aging D TIER Melanotan II - cosmetic tanning compound. Not an anti-aging peptide. Side effect profile makes it hard to justify here Dihexa - cognitive peptide with theoretical relevance but very limited data and safety concerns around its mechanism The compounds in S and A tier are there because they address the root drivers of aging. GH decline, immune dysfunction, mitochondrial decay, tissue breakdown, and chronic inflammation. Everything below supports those areas or targets something more specific This is educational and research discussion only. Not medical advice What would you move? Drop your rankings below

peptides cheatsheet A quick reference guide on the most discussed compounds... Not medical advice. Purely educational for research purposes. ALWAYS do your own research. REPAIR, RECOVERY & AGING BPC-157 – gut lining, healing injuries, tissue repair TB-500 – cuts down inflammation, helps muscle repair and flexibility GHK-Cu – skin repair, collagen, wound healing, hair benefits KPV – calms gut irritation and supports immune balance Epithalon – circadian rhythm, cellular cleanup, healthier aging NAD+ – powers brain cells, boosts energy, longevity angle Glutathione – detox, immunity, skin clarity Thymosin Alpha-1 – helps regulate immune response and inflammation SS-31 / Elamipretide – protects mitochondria, cell energy, anti-aging MASS, POWER & RECOVERY (GH/IGF AXIS) Sermorelin – natural GH support, lean mass, better sleep, recovery Ipamorelin – GH release, deep sleep, healing, mild and clean CJC-1295 + Ipamorelin – the classic GH stack for recovery and fat loss GHRP-2 – growth, appetite kick, recovery GHRP-6 – powerful appetite stimulation plus muscle gain IGF-1 LR3 – systemic tissue repair and muscle growth, not for beginners IGF-1 DES – spot application for localized growth and healing, advanced Follistatin-344 – leans toward muscle and strength support Hexarelin – strong GH pulse, advanced, can spike prolactin HGH – the standard for recovery, body recomp, sleep, anti-aging WEIGHT LOSS & METABOLIC HEALTH Semaglutide – kills appetite, drives weight loss, improves blood sugar, strongest human data here Tirzepatide – dual pathway for appetite, fat loss, insulin function Retatrutide – triple pathway, aggressive fat loss, better at maintaining lean muscle, still research only Tesamorelin – specifically attacks belly/visceral fat, FDA context exists Cagrilintide – appetite suppression via amylin pathway AOD-9604 – fat targeting, but FDA has flagged safety concerns with limited data HGH Fragment 176-191 – fat burning while holding onto muscle, mostly animal studies 5-Amino-1MQ – NNMT inhibition for metabolism, human data scarce MOTS-c – mitochondrial energy and fat burning, experimental Mazdutide / Survodutide – newer players in weight regulation, still investigational BRAIN, MOOD & SLEEP Semax – sharp focus, memory lift, mood, mental energy, can feel stimulating Selank – chills anxiety, improves mood, calm focus, often paired with Semax DSIP – helps with sleep quality and calming the nervous system Epithalon – also used here for sleep cycle support (see longevity) Dihexa – cognitive boost, highly experimental, not for casual use Kisspeptin-10 – mood, libido, hormone signaling SKIN, HAIR & LOOKS GHK-Cu – injectable or topical for collagen, texture, wound healing, hair Melanotan II – tanning without sun plus libido boost, watch for nausea and mole changes RU-58841 – topical anti-DHT at the follicle for hair retention Oral collagen peptides – easy entry for skin hydration, joints, elasticity SEX & LIBIDO PT-141 / Bremelanotide – works on the brain's arousal centers (not vascular), FDA version exists for women Melanotan II – tanning first, libido second Oxytocin – bonding, closeness, mood, effects aren't consistent for everyone Kisspeptin-10 – libido and upstream hormone signaling GUT & SYSTEMIC INFLAMMATION BPC-157 – repairs gut lining, digestive support, lowers inflammation KPV – GI-specific and general inflammatory conditions Glutathione – detox and immune support (listed above, but fits here too) LL-37 – antimicrobial and immune defense, very limited human work POPULAR STACKS Wolverine (BPC + TB-500) – soft tissue and recovery GLOW – BPC + TB + GHK-Cu for skin, hair, and healing KLOW – GLOW + KPV adds gut and inflammation coverage CJC + Ipamorelin – the go-to GH support stack TRT & HORMONE MANAGEMENT Test C / Test E – standard TRT bases HCG – keeps fertility and testicular function alive on TRT Enclomiphene – SERM that raises natural testosterone without shutting you down Anastrozole – manages estrogen when needed on TRT Gonadorelin – HCG alternative for LH stimulation Reminder: this is educational discussion, zero medical advice!