VIP - Research Profile & Reviews

Research Overview

Vasoactive Intestinal Peptide (VIP) is a naturally occurring 28-amino-acid neuropeptide belonging to the glucagon/secretin superfamily. First isolated from porcine intestine in 1970 by Dr. Sami Said, VIP is widely distributed in the central and peripheral nervous system, gastrointestinal tract, pancreas, and immune cells. It acts through two G protein-coupled receptors, VPAC1 and VPAC2, which are expressed throughout the body.

VIP's mechanism of action is remarkably pleiotropic. In the immune system, it acts as a potent anti-inflammatory agent by inhibiting the production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-12) while promoting anti-inflammatory cytokines (IL-10). It induces regulatory T-cell differentiation and inhibits Th1 and Th17 responses. In the cardiovascular system, VIP is a potent vasodilator. In the nervous system, it functions as a neurotransmitter and neuroprotective agent, promoting neuronal survival and stimulating the growth of neural progenitor cells.

Research has explored VIP's therapeutic potential across numerous conditions. Studies in ARDS and COVID-19 (as Aviptadil/Zyesami) showed improvements in oxygenation and survival. Animal research has demonstrated efficacy in autoimmune models including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. VIP deficiency has been linked to CIRS (Chronic Inflammatory Response Syndrome), and VIP replacement therapy is used in some functional medicine protocols. Its role in circadian rhythm regulation through the suprachiasmatic nucleus also links it to sleep and metabolic health.

Documented Research Effects

Immune Support Gut Health Sleep Quality Cognitive Function

Dosage & Protocol

Typical Dose Range

50 – 500

mcg per dose

Frequency

1x daily (intranasal) or 1-3x weekly (subQ)

Cycle Length

4-12 weeks

Common Vial Sizes

5

Calculate exact draw volumes and reconstitution steps.

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Dosage information is for research reference only. Always follow established research protocols. Not medical advice.

Storage & Handling

Lyophilized Powder

Temperature -20°C

Shelf Life 2+ years

Reconstituted Solution

Temperature 2-8°C

Shelf Life 2-3 weeks

Frequently Asked Questions

VIP is researched and used clinically for Chronic Inflammatory Response Syndrome (CIRS), where it helps normalize dysregulated immune function. It has been studied in ARDS/COVID-19 respiratory failure (as Aviptadil), autoimmune conditions (rheumatoid arthritis, IBD, multiple sclerosis), and pulmonary hypertension. In functional medicine, VIP nasal spray is used to address mold illness, biotoxin-related inflammation, and hypothalamic-pituitary dysfunction.

VIP is most commonly administered intranasally for CIRS and inflammatory conditions, typically at doses of 50-500 mcg per spray. Intranasal delivery provides rapid absorption and direct access to CNS receptors. It can also be given by subcutaneous or intravenous injection for systemic effects. For CIRS protocols (Shoemaker protocol), the typical dose is 50 mcg intranasally 4 times daily, though protocols vary by practitioner.

Yes, VIP is a relatively fragile peptide that requires careful storage. Lyophilized VIP should be stored at -20 degrees Celsius. After reconstitution, it must be refrigerated at 2-8 degrees Celsius and used within 2-3 weeks. Intranasal VIP solutions should also be kept refrigerated between uses. Avoid exposure to heat, light, and repeated freeze-thaw cycles, as VIP degrades more quickly than many other peptides.

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